A Germline Point Mutation in the MYC-FBW7 Phosphodegron Initiates Hematopoietic Malignancies

Oncogenic activation of MYC in cancers predominantly involves increased transcription rather than coding region mutations. However, MYC-dependent lymphomas frequently contain point mutations in the MYC phospho-degron, including at threonine-58 (T58), where phosphorylation permits binding by the FBW7...

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Detalles Bibliográficos
Autores principales: Freie, Brian, Carroll, Patrick A., Varnum-Finney, Barbara J., Ramani, Vijay, Bernstein, Irwin, Eisenman, Robert N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634767/
https://www.ncbi.nlm.nih.gov/pubmed/37961183
http://dx.doi.org/10.1101/2023.10.23.563660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634767/
https://www.ncbi.nlm.nih.gov/pubmed/37961183
http://dx.doi.org/10.1101/2023.10.23.563660

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