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Collapse of late endosomal pH elicits a rapid Rab7 response via V-ATPase and RILP
Endosomal-lysosomal trafficking entails progressive acidification of endosomal compartments by the H(+)-V-ATPase to reach low lysosomal pH. Disruption of proper pH affects lysosomal function and the balance of protein synthesis and degradation (proteostasis). Disruption of endosomal pH also impairs...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634777/ https://www.ncbi.nlm.nih.gov/pubmed/37961579 http://dx.doi.org/10.1101/2023.10.24.563658 |