Spatially resolved DNP-assisted NMR illuminates the conformational ensemble of α-synuclein in intact viable cells

The protein α-syn adopts a wide variety of conformations including an intrinsically disordered monomeric form and an α-helical rich membrane-associated form that is thought to play an important role in cellular membrane processes. However, despite the high affinity of α-syn for membranes, evidence t...

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Detalles Bibliográficos
Autores principales: Kragelj, Jaka, Ghosh, Rupam, Xiao, Yiling, Dumarieh, Rania, Lagasca, Dominique, Krishna, Sakshi, Frederick, Kendra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634803/
https://www.ncbi.nlm.nih.gov/pubmed/37961511
http://dx.doi.org/10.1101/2023.10.24.563877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634803/
https://www.ncbi.nlm.nih.gov/pubmed/37961511
http://dx.doi.org/10.1101/2023.10.24.563877

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