Extracellular domain, hinge, and transmembrane determinants affecting surface CD4 expression of a novel anti-HIV chimeric antigen receptor (CAR) construct

Chimeric antigen receptor (CAR)-T cells have demonstrated clinical potential, but current receptors still need improvements to be successful against chronic HIV infection. In this study, we address some requirements of CAR motifs for strong surface expression of a novel anti-HIV CAR by evaluating im...

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Detalles Bibliográficos
Autores principales: Zenere, Giorgio, Wu, Chengxiang, Midkiff, Cecily C., Johnson, Nathan M., Grice, Christopher P., Wimley, William C., Kaur, Amitinder, Braun, Stephen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634810/
https://www.ncbi.nlm.nih.gov/pubmed/37961145
http://dx.doi.org/10.1101/2023.10.25.563930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634810/
https://www.ncbi.nlm.nih.gov/pubmed/37961145
http://dx.doi.org/10.1101/2023.10.25.563930

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