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Energy metabolism modulates the regulatory impact of activators on gene expression

Gene expression is a regulated process fueled by ATP consumption. Therefore, regulation must be coupled to constraints imposed by the level of energy metabolism. Here, we explore this relationship both theoretically and experimentally. A stylized mathematical model predicts that activators of gene e...

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Detalles Bibliográficos
Autores principales: Qiao, Sha, Bernasek, Sebastian, Gallagher, Kevin D., Yamada, Shigehiro, Bagheri, Neda, Amaral, Luis A.N., Carthew, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634812/
https://www.ncbi.nlm.nih.gov/pubmed/37961620
http://dx.doi.org/10.1101/2023.10.24.563842