Colloidal aggregation confounds cell-based Covid-19 antiviral screens

Colloidal aggregation is one of the largest contributors to false-positives in early drug discovery and chemical biology. Much work has focused on its impact on pure-protein screens; here we consider aggregations role in cell-based infectivity assays in Covid-19 drug repurposing. We began by investi...

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Detalles Bibliográficos
Autores principales: Glenn, Isabella S., Hall, Lauren N., Khalid, Mir M., Ott, Melanie, Shoichet, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634915/
https://www.ncbi.nlm.nih.gov/pubmed/37961552
http://dx.doi.org/10.1101/2023.10.27.564435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634915/
https://www.ncbi.nlm.nih.gov/pubmed/37961552
http://dx.doi.org/10.1101/2023.10.27.564435

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