Unearthing SRSF1’s Novel Function in Binding and Unfolding of RNA G-Quadruplexes

SRSF1 governs splicing of over 1,500 mRNA transcripts. SRSF1 contains two RNA-recognition motifs (RRMs) and a C-terminal Arg/Ser-rich region (RS). It has been thought that SRSF1 RRMs exclusively recognize single-stranded exonic splicing enhancers, while RS lacks RNA-binding specificity. With our suc...

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Detalles Bibliográficos
Autores principales: De Silva, Naiduwadura Ivon Upekala, Lehman, Nathan, Fargason, Talia, Paul, Trenton, Zhang, Zihan, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634998/
https://www.ncbi.nlm.nih.gov/pubmed/37961538
http://dx.doi.org/10.1101/2023.10.30.563137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634998/
https://www.ncbi.nlm.nih.gov/pubmed/37961538
http://dx.doi.org/10.1101/2023.10.30.563137

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