Distinct Activation Mechanisms of CXCR4 and ACKR3 Revealed by Single-Molecule Analysis of their Conformational Landscapes

Canonical chemokine receptor CXCR4 and atypical receptor ACKR3 both respond to CXCL12 but induce different intracellular effector responses to regulate cell migration: CXCR4 couples to G proteins and arrestins, while ACKR3 is arrestin-biased. CXCR4 also signals only in response to CXCL12, whereas AC...

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Detalles Bibliográficos
Autores principales: Schafer, Christopher T., Pauszek III, Raymond F., Gustavsson, Martin, Handel, Tracy M., Millar, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635023/
https://www.ncbi.nlm.nih.gov/pubmed/37961571
http://dx.doi.org/10.1101/2023.10.31.564925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635023/
https://www.ncbi.nlm.nih.gov/pubmed/37961571
http://dx.doi.org/10.1101/2023.10.31.564925

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