Cargando…

Autophagy regulates tumor growth and metastasis

The role of autophagy in tumorigenesis and tumor metastasis remains poorly understood. Here we show that inhibition of autophagy stabilizes the transcription factor Twist1 through Sequestosome-1 (SQSTM1, also known as p62) and thus increases cell proliferation, migration, and epithelial-mesenchymal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qiang, Lei, Zhao, Baozhong, Ming, Mei, Wang, Ning, He, Tong-Chuan, Hwang, Seungmin, Thorburn, Andrew, He, Yu-Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635024/ https://www.ncbi.nlm.nih.gov/pubmed/37961427 http://dx.doi.org/10.1101/2023.10.31.564991

Ejemplares similares

Autophagy regulates selective HMGB1 release in tumor cells that are destined to die
por: Thorburn, Jacqueline, et al.
Publicado: (2008)

Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival
por: Zhao, Baozhong, et al.
Publicado: (2016)

Inhibition of chaperone-mediated autophagy reduces tumor growth and metastasis and promotes drug sensitivity in colorectal cancer
por: Xuan, Ying, et al.
Publicado: (2021)

Regulation of Apoptosis by Autophagy to Enhance Cancer Therapy
por: Tompkins, Kenneth D., et al.
Publicado: (2019)

Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair
por: Shah, Palak, et al.
Publicado: (2018)

Inhibition of autophagy impairs tumor cell invasion in an organotypic model
por: Macintosh, Robin L., et al.
Publicado: (2012)

Autophagy and Noroviruses
por: Furlong, Kevin, et al.
Publicado: (2019)

Autophagy-dependent regulation of tumor metastasis by myeloid cells
por: Jinushi, Masahisa, et al.
Publicado: (2017)

Therapeutic Targeting of Autophagy()
por: Towers, Christina G., et al.
Publicado: (2016)

Autophagy and Its Effects: Making Sense of Double-Edged Swords
por: Thorburn, Andrew
Publicado: (2014)

Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent
por: Morgan, Michael J, et al.
Publicado: (2014)

Oxidized Phospholipids in Tumor Microenvironment Stimulate Tumor Metastasis via Regulation of Autophagy
por: Seok, Jin Kyung, et al.
Publicado: (2021)

Using BRAF(V600E) as a marker of autophagy dependence in pediatric brain tumors
por: Levy, Jean M Mulcahy, et al.
Publicado: (2014)

CTGF-mediated autophagy-senescence transition in tumor stroma promotes anabolic tumor growth and metastasis
por: Prabhu, Varun V., et al.
Publicado: (2012)

Regulation of Tumor Growth and Metastasis: The Role of Tumor Microenvironment
por: Goubran, Hadi A, et al.
Publicado: (2014)

CircHADHA-augmented autophagy suppresses tumor growth of colon cancer by regulating autophagy-related gene via miR-361
por: Shi, Ying, et al.
Publicado: (2022)

Autophagy complexes cell death by necroptosis
por: Goodall, Megan L., et al.
Publicado: (2016)

The role of platelets in the regulation of tumor growth and metastasis: the mechanisms and targeted therapy
por: Liao, Kaili, et al.
Publicado: (2023)

Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells
por: Qin, Wenjie, et al.
Publicado: (2015)

The role of autophagy in regulating metabolism in the tumor microenvironment
por: Zhang, Panpan, et al.
Publicado: (2021)

Autophagy inhibition improves anti-cancer drugs via FOXO3a activation
por: Fitzwalter, Brent E., et al.
Publicado: (2018)

Tetrandrine Suppresses Cancer Angiogenesis and Metastasis in 4T1 Tumor Bearing Mice
por: Gao, Jian-Li, et al.
Publicado: (2013)

Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts
por: Yttersian Sletta, Kristine, et al.
Publicado: (2017)

m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
por: Yang, Seungwon, et al.
Publicado: (2019)

Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations
por: Towers, Christina G., et al.
Publicado: (2019)

Cathepsin K regulates the tumor growth and metastasis by IL-17/CTSK/EMT axis and mediates M2 macrophage polarization in castration-resistant prostate cancer
por: Wu, Ning, et al.
Publicado: (2022)

MicroRNA-493 Suppresses Tumor Growth, Invasion and Metastasis of Lung Cancer by Regulating E2F1
por: Gu, Yixue, et al.
Publicado: (2014)

Apoptosis, autophagy, necroptosis, and cancer metastasis
por: Su, Zhenyi, et al.
Publicado: (2015)

Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy
por: Park, Sungwoo, et al.
Publicado: (2016)

‘Doubling down’ on the autophagy pathway to suppress tumor growth
por: Leidal, Andrew M., et al.
Publicado: (2014)

Quo vadis? Interferon-inducible GTPases go to their target membranes via the LC3-conjugation system of autophagy
por: Choi, Jayoung, et al.
Publicado: (2016)

Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
por: Mulcahy Levy, Jean M, et al.
Publicado: (2017)

The metastasis suppressor gene KISS-1 regulates osteosarcoma apoptosis and autophagy processes
por: Yin, Yiran, et al.
Publicado: (2017)

Retraction: MicroRNA-493 Suppresses Tumor Growth, Invasion and Metastasis of Lung cancer by Regulating E2F1
por: Gu, Yixue, et al.
Publicado: (2019)

Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis
por: Whipple, Chery A., et al.
Publicado: (2008)

Therapeutic silence of pleiotrophin by targeted delivery of siRNA and its effect on the inhibition of tumor growth and metastasis
por: Zha, Lisha, et al.
Publicado: (2017)

Down-Regulation of an Autophagy-Related Gene SERPINA1 as a Superior Prognosis Biomarker Associates with Relapse and Distant Metastasis in Colon Adenocarcinoma
por: Fu, Chen, et al.
Publicado: (2021)

Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways
por: GAO, JIAN-LI, et al.
Publicado: (2013)

MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1
por: Yang, Jing, et al.
Publicado: (2018)

FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma
por: Li, Dan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ftdkf1holncov1js6h8c5ooo19