Covalent Degrader of the Oncogenic Transcription Factor β-Catenin

β-catenin (CTNNB1) is an oncogenic transcription factor that is important in cell-cell adhesion and transcription of cell proliferation and survival genes that drives the pathogenesis of many different types of cancers. However, direct pharmacological targeting of CTNNB1 has remained challenging dee...

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Detalles Bibliográficos
Autores principales: Gowans, Flor A., Forte, Nafsika, Hatcher, Justin, Huang, Oscar W., Wang, Yangzhi, Poblano, Belen E. Altamirano, Wertz, Ingrid E., Nomura, Daniel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635039/
https://www.ncbi.nlm.nih.gov/pubmed/37961622
http://dx.doi.org/10.1101/2023.10.31.565018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635039/
https://www.ncbi.nlm.nih.gov/pubmed/37961622
http://dx.doi.org/10.1101/2023.10.31.565018

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