Design of efficient artificial enzymes using crystallographically-enhanced conformational sampling

The ability to create efficient artificial enzymes for any chemical reaction is of great interest. Here, we describe a computational design method for increasing catalytic efficiency of de novo enzymes to a level comparable to their natural counterparts without relying on directed evolution. Using s...

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Detalles Bibliográficos
Autores principales: Rakotoharisoa, Rojo V., Seifinoferest, Behnoush, Zarifi, Niayesh, Miller, Jack D.M., Rodriguez, Joshua M., Thompson, Michael C., Chica, Roberto A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635043/
https://www.ncbi.nlm.nih.gov/pubmed/37961474
http://dx.doi.org/10.1101/2023.11.01.564846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635043/
https://www.ncbi.nlm.nih.gov/pubmed/37961474
http://dx.doi.org/10.1101/2023.11.01.564846

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