LARP1 senses free ribosomes to coordinate supply and demand of ribosomal proteins

Terminal oligopyrimidine motif-containing mRNAs (TOPs) encode all ribosomal proteins in mammals and are regulated to tune ribosome synthesis to cell state. Previous studies implicate LARP1 in 40S- or 80S-ribosome complexes that repress and stabilize TOPs. However, a mechanistic understanding of how...

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Detalles Bibliográficos
Autores principales: Saba, James A., Huang, Zixuan, Schole, Kate L., Ye, Xianwen, Bhatt, Shrey D., Li, Yi, Timp, Winston, Cheng, Jingdong, Green, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635049/
https://www.ncbi.nlm.nih.gov/pubmed/37961604
http://dx.doi.org/10.1101/2023.11.01.565189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635049/
https://www.ncbi.nlm.nih.gov/pubmed/37961604
http://dx.doi.org/10.1101/2023.11.01.565189

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