One-carbon unit supplementation fuels tumor-infiltrating T cells and augments checkpoint blockade

Nucleotides perform important metabolic functions, carrying energy and feeding nucleic acid synthesis. Here, we use isotope tracing-mass spectrometry to quantitate the contributions to purine nucleotides of salvage versus de novo synthesis. We further explore the impact of augmenting a key precursor...

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Detalles Bibliográficos
Autores principales: Xu, Xincheng, Chen, Zihong, Bartman, Caroline R., Xing, Xi, Olszewski, Kellen, Rabinowitz, Joshua D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635052/
https://www.ncbi.nlm.nih.gov/pubmed/37961420
http://dx.doi.org/10.1101/2023.11.01.565193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635052/
https://www.ncbi.nlm.nih.gov/pubmed/37961420
http://dx.doi.org/10.1101/2023.11.01.565193

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