A single locus determines praziquantel response in Schistosoma mansoni

We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci (QTL) situated on chromosome 2 and chromosome 3. We reanalyzed this GWAS using the latest (v10) genome assembly showing...

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Autores principales: Chevalier, Frédéric D., Clec’h, Winka Le, Berriman, Matthew, Anderson, Timothy J.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635054/
https://www.ncbi.nlm.nih.gov/pubmed/37961217
http://dx.doi.org/10.1101/2023.11.01.565202
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author Chevalier, Frédéric D.
Clec’h, Winka Le
Berriman, Matthew
Anderson, Timothy J.C.
author_facet Chevalier, Frédéric D.
Clec’h, Winka Le
Berriman, Matthew
Anderson, Timothy J.C.
author_sort Chevalier, Frédéric D.
collection PubMed
description We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci (QTL) situated on chromosome 2 and chromosome 3. We reanalyzed this GWAS using the latest (v10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response. These results reveal that praziquantel response is monogenic and demonstrates the importance of high-quality genomic information.
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spelling pubmed-106350542023-11-13 A single locus determines praziquantel response in Schistosoma mansoni Chevalier, Frédéric D. Clec’h, Winka Le Berriman, Matthew Anderson, Timothy J.C. bioRxiv Article We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci (QTL) situated on chromosome 2 and chromosome 3. We reanalyzed this GWAS using the latest (v10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response. These results reveal that praziquantel response is monogenic and demonstrates the importance of high-quality genomic information. Cold Spring Harbor Laboratory 2023-11-04 /pmc/articles/PMC10635054/ /pubmed/37961217 http://dx.doi.org/10.1101/2023.11.01.565202 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Chevalier, Frédéric D.
Clec’h, Winka Le
Berriman, Matthew
Anderson, Timothy J.C.
A single locus determines praziquantel response in Schistosoma mansoni
title A single locus determines praziquantel response in Schistosoma mansoni
title_full A single locus determines praziquantel response in Schistosoma mansoni
title_fullStr A single locus determines praziquantel response in Schistosoma mansoni
title_full_unstemmed A single locus determines praziquantel response in Schistosoma mansoni
title_short A single locus determines praziquantel response in Schistosoma mansoni
title_sort single locus determines praziquantel response in schistosoma mansoni
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635054/
https://www.ncbi.nlm.nih.gov/pubmed/37961217
http://dx.doi.org/10.1101/2023.11.01.565202
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