Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)

Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the precise mechanisms remain elusive. Using a well-defined drug-gene...

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Detalles Bibliográficos
Autores principales: Zhang, Ting, Ambrodji, Alisa, Huang, Huixing, Bouchonville, Kelly J., Etheridge, Amy S., Schmidt, Remington E., Bembenek, Brianna M., Temesgen, Zoey B., Wang, Zhiquan, Innocenti, Federico, Stroka, Deborah, Diasio, Robert B., Largiadèr, Carlo R., Offer, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635067/
https://www.ncbi.nlm.nih.gov/pubmed/37961517
http://dx.doi.org/10.1101/2023.11.01.565230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635067/
https://www.ncbi.nlm.nih.gov/pubmed/37961517
http://dx.doi.org/10.1101/2023.11.01.565230

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