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Engineered immunomodulatory extracellular vesicles derived from epithelial cells acquire capacity for positive and negative T cell co-stimulation in cancer and autoimmunity
Extracellular vesicles (EVs) are generated by all cells and systemic administration of allogenic EVs derived from epithelial and mesenchymal cells have been shown to be safe, despite carrying an array of functional molecules, including thousands of proteins. To address whether epithelial cells deriv...
Autores principales: | Kugeratski, Fernanda G., LeBleu, Valerie S., Dowlatshahi, Dara P., Sugimoto, Hikaru, Arian, Kent A., Fan, Yibo, Huang, Li, Wells, Danielle, Lilla, Sergio, Hodge, Kelly, Zanivan, Sara, McAndrews, Kathleen M., Kalluri, Raghu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635085/ https://www.ncbi.nlm.nih.gov/pubmed/37961535 http://dx.doi.org/10.1101/2023.11.02.565371 |
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