Identification of Small Molecule Ligand Binding Sites On and In the ARNT PAS-B Domain

Transcription factors are generally challenging to target with small molecule inhibitors due to their structural plasticity and lack of catalytic sites. Notable exceptions to this include a number of transcription factors which are naturally ligand-regulated, a strategy we have successfully exploite...

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Detalles Bibliográficos
Autores principales: Xu, Xingjian, Marcelino, Leandro Pimentel, Favaro, Denize C., Silvestrini, Marion L., Solazzo, Riccardo, Chong, Lillian T., Gardner, Kevin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635134/
https://www.ncbi.nlm.nih.gov/pubmed/37961463
http://dx.doi.org/10.1101/2023.11.03.565595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635134/
https://www.ncbi.nlm.nih.gov/pubmed/37961463
http://dx.doi.org/10.1101/2023.11.03.565595

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