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Identification of Small Molecule Ligand Binding Sites On and In the ARNT PAS-B Domain
Transcription factors are generally challenging to target with small molecule inhibitors due to their structural plasticity and lack of catalytic sites. Notable exceptions to this include a number of transcription factors which are naturally ligand-regulated, a strategy we have successfully exploite...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635134/ https://www.ncbi.nlm.nih.gov/pubmed/37961463 http://dx.doi.org/10.1101/2023.11.03.565595 |