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Mapping the landscape of lineage-specific dynamic regulation of gene expression using single-cell transcriptomics and application to genetics of complex disease

Single-cell transcriptome data can provide insights into how genetic variation influences biological processes involved in human biology and disease. However, the identification of gene-level associations in distinct cell types faces several challenges, including the limited reference resource from...

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Detalles Bibliográficos
Autores principales: Abe, Hanna, Lin, Phillip, Zhou, Dan, Ruderfer, Douglas M., Gamazon, Eric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635195/
https://www.ncbi.nlm.nih.gov/pubmed/37961453
http://dx.doi.org/10.1101/2023.10.24.23297476