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Mapping the landscape of lineage-specific dynamic regulation of gene expression using single-cell transcriptomics and application to genetics of complex disease
Single-cell transcriptome data can provide insights into how genetic variation influences biological processes involved in human biology and disease. However, the identification of gene-level associations in distinct cell types faces several challenges, including the limited reference resource from...
Autores principales: | Abe, Hanna, Lin, Phillip, Zhou, Dan, Ruderfer, Douglas M., Gamazon, Eric R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635195/ https://www.ncbi.nlm.nih.gov/pubmed/37961453 http://dx.doi.org/10.1101/2023.10.24.23297476 |
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