Fine-mapping causal tissues and genes at disease-associated loci

Heritable diseases often manifest in a highly tissue-specific manner, with different disease loci mediated by genes in distinct tissues or cell types. We propose Tissue-Gene Fine-Mapping (TGFM), a fine-mapping method that infers the posterior probability (PIP) for each gene-tissue pair to mediate a...

Descripción completa

Detalles Bibliográficos
Autores principales: Strober, Benjamin J., Zhang, Martin Jinye, Amariuta, Tiffany, Rossen, Jordan, Price, Alkes L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635248/
https://www.ncbi.nlm.nih.gov/pubmed/37961337
http://dx.doi.org/10.1101/2023.11.01.23297909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635248/
https://www.ncbi.nlm.nih.gov/pubmed/37961337
http://dx.doi.org/10.1101/2023.11.01.23297909

Ejemplares similares