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DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity

Pathogenic tau accumulation fuels neurodegeneration in Alzheimer’s disease (AD). Enhancing aging brain’s resilience to tau pathology would lead to novel therapeutic strategies. DAP12 (DNAX-activation protein 12) is critically involved in microglial immune responses. Previous studies have showed that...

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Detalles Bibliográficos
Autores principales: Chen, Hao, Fan, Li, Guo, Qi, Wong, Man Ying, Yu, Fangmin, Foxe, Nessa, Wang, Winston, Nessim, Aviram, Carling, Gillian, Liu, Bangyan, Lopez-Lee, Chloe, Huang, Yige, Amin, Sadaf, Mok, Sue-Ann, Song, Won-min, Zhang, Bin, Ma, Qin, Fu, Hongjun, Gan, Li, Luo, Wenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635319/
https://www.ncbi.nlm.nih.gov/pubmed/37961627
http://dx.doi.org/10.21203/rs.3.rs-3454358/v1