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DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity
Pathogenic tau accumulation fuels neurodegeneration in Alzheimer’s disease (AD). Enhancing aging brain’s resilience to tau pathology would lead to novel therapeutic strategies. DAP12 (DNAX-activation protein 12) is critically involved in microglial immune responses. Previous studies have showed that...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Journal Experts
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635319/ https://www.ncbi.nlm.nih.gov/pubmed/37961627 http://dx.doi.org/10.21203/rs.3.rs-3454358/v1 |