Using Prior Knowledge on Systems Through PBPK to Gain Further Insight into Routine Clinical Data on Trough Concentrations: The Case of Tacrolimus in Chronic Kidney Disease

BACKGROUND: Routine therapeutic drug monitoring (TDM) relies heavily on measuring trough drug concentrations. Trough concentrations are affected not only by drug bioavailability and clearance, but also by various patient and disease factors and the volume of distribution. This often makes interpreti...

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Detalles Bibliográficos
Autores principales: El-Khateeb, Eman, Chinnadurai, Rajkumar, Al Qassabi, Jokha, Scotcher, Daniel, Darwich, Adam S., Kalra, Philip A., Rostami-Hodjegan, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Therapeutic Drug Monitoring 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635338/
https://www.ncbi.nlm.nih.gov/pubmed/37315152
http://dx.doi.org/10.1097/FTD.0000000000001108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635338/
https://www.ncbi.nlm.nih.gov/pubmed/37315152
http://dx.doi.org/10.1097/FTD.0000000000001108

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