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scPrisma infers, filters and enhances topological signals in single-cell data using spectral template matching

Single-cell RNA sequencing has been instrumental in uncovering cellular spatiotemporal context. This task is challenging as cells simultaneously encode multiple, potentially cross-interfering, biological signals. Here we propose scPrisma, a spectral computational method that uses topological priors...

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Detalles Bibliográficos
Autores principales: Karin, Jonathan, Bornfeld, Yonathan, Nitzan, Mor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635821/
https://www.ncbi.nlm.nih.gov/pubmed/36849830
http://dx.doi.org/10.1038/s41587-023-01663-5