GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers

X-chromosome inactivation (XCI) balances gene expression between the sexes in female mammals. Shortly after fertilization, upregulation of Xist RNA from one X chromosome initiates XCI, leading to chromosome-wide gene silencing. XCI is maintained in all cell types, except the germ line and the plurip...

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Detalles Bibliográficos
Autores principales: Ravid Lustig, Liat, Sampath Kumar, Abhishek, Schwämmle, Till, Dunkel, Ilona, Noviello, Gemma, Limberg, Elodie, Weigert, Raha, Pacini, Guido, Buschow, René, Ghauri, Afrah, Stötzel, Maximilian, Wittler, Lars, Meissner, Alexander, Schulz, Edda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635832/
https://www.ncbi.nlm.nih.gov/pubmed/37932452
http://dx.doi.org/10.1038/s41556-023-01266-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635832/
https://www.ncbi.nlm.nih.gov/pubmed/37932452
http://dx.doi.org/10.1038/s41556-023-01266-x

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