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Progesterone activation of β(1)-containing BK channels involves two binding sites

Progesterone (≥1 µM) is used in recovery of cerebral ischemia, an effect likely contributed to by cerebrovascular dilation. The targets of this progesterone action are unknown. We report that micromolar (µM) progesterone activates mouse cerebrovascular myocyte BK channels; this action is lost in β(1...

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Detalles Bibliográficos
Autores principales: North, Kelsey C., Shaw, Andrew A., Bukiya, Anna N., Dopico, Alex M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636063/
https://www.ncbi.nlm.nih.gov/pubmed/37945687
http://dx.doi.org/10.1038/s41467-023-42827-w