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Selective dopamine D2 receptor deletion from Nkx6.2 expressing cells causes impaired cognitive, motivation and anxiety phenotypes in mice

Abnormal dopamine neurotransmission is a common trait of some psychiatric diseases, like schizophrenia or bipolar disorder. Excessive dopaminergic tone in subcortical brain regions is associated with psychotic episodes, while reduced prefrontal dopaminergic activity is associated with impaired cogni...

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Detalles Bibliográficos
Autores principales: Bechelli, Lucila, Tomasella, Eugenia, Cardoso, Sofia Lopez, Belmonte, Martina, Gelman, Diego M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636105/
https://www.ncbi.nlm.nih.gov/pubmed/37945756
http://dx.doi.org/10.1038/s41598-023-46954-8