The common H232 STING allele shows impaired activities in DNA sensing, susceptibility to viral infection, and in monocyte cell function, while the HAQ variant possesses wild-type properties

Different innate immune pathways converge to Stimulator of interferon genes (STING) and trigger type I interferon responses after recognition of abnormal nucleic acids in the cells. This non-redundant function renders STING a major player in immunosurveillance, and an emerging target for cancer and...

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Detalles Bibliográficos
Autores principales: Froechlich, Guendalina, Finizio, Arianna, Napolano, Alessandra, Amiranda, Sara, De Chiara, Arianna, Pagano, Pasqualina, Mallardo, Massimo, Leoni, Guido, Zambrano, Nicola, Sasso, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636114/
https://www.ncbi.nlm.nih.gov/pubmed/37945588
http://dx.doi.org/10.1038/s41598-023-46830-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636114/
https://www.ncbi.nlm.nih.gov/pubmed/37945588
http://dx.doi.org/10.1038/s41598-023-46830-5

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