Structures of the DarR transcription regulator reveal unique modes of second messenger and DNA binding

The mycobacterial repressor, DarR, a TetR family regulator (TFR), was the first transcription regulator shown to bind c-di-AMP. However, the molecular basis for this interaction and the mechanism involved in DNA binding by DarR remain unknown. Here we describe DarR-c-di-AMP and DarR-DNA structures a...

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Detalles Bibliográficos
Autores principales: Schumacher, Maria A., Lent, Nicholas, Chen, Vincent B., Salinas, Raul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636190/
https://www.ncbi.nlm.nih.gov/pubmed/37945601
http://dx.doi.org/10.1038/s41467-023-42823-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636190/
https://www.ncbi.nlm.nih.gov/pubmed/37945601
http://dx.doi.org/10.1038/s41467-023-42823-0

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