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Orai1α and Orai1β support calcium entry and mammosphere formation in breast cancer stem cells

Orai1 is the pore-forming subunit of the Ca(2+)-release activated Ca(2+) channels that mediate store-operated Ca(2+) entry (SOCE) in excitable and non-excitable cells. Two Orai1 forms have been identified in mammalian cells, the full-length variant Orai1α, and the short form Orai1β, lacking the N-te...

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Detalles Bibliográficos
Autores principales: Jardin, Isaac, Alvarado, Sandra, Jimenez-Velarde, Vanesa, Nieto-Felipe, Joel, Lopez, Jose J., Salido, Gines M., Smani, Tarik, Rosado, Juan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636192/
https://www.ncbi.nlm.nih.gov/pubmed/37945647
http://dx.doi.org/10.1038/s41598-023-46946-8