α-Synuclein expression in response to bacterial ligands and metabolites in gut enteroendocrine cells: an in vitro proof of concept study

Caudo-rostral migration of pathological forms of α-synuclein from the gut to the brain is proposed as an early feature in Parkinson’s disease pathogenesis, but the underlying mechanisms remain unknown. Intestinal epithelial enteroendocrine cells sense and respond to numerous luminal signals, includi...

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Detalles Bibliográficos
Autores principales: Hurley, Michael J, Menozzi, Elisa, Koletsi, Sofia, Bates, Rachel, Gegg, Matthew E, Chau, Kai-Yin, Blottière, Hervé M, Macnaughtan, Jane, Schapira, Anthony H V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636561/
https://www.ncbi.nlm.nih.gov/pubmed/37953845
http://dx.doi.org/10.1093/braincomms/fcad285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636561/
https://www.ncbi.nlm.nih.gov/pubmed/37953845
http://dx.doi.org/10.1093/braincomms/fcad285

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