Cargando…

Knockdown of LRRK2 inhibits the progression of lung cancer by regulating TLR4/NF-κB pathways and NLRP3 inflammasome

Leucine-rich repeat kinase 2 (LRRK2) plays an important role in a variety of inflammatory diseases, as well as peripheral and central immune responses. At present, there are few reports about the role of LRRK2 in lung cancer, and need to be further explored. The main purpose of this study is to expl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Junfang, Yang, Shumei, Wu, Hua, Huang, Yongcheng, Miao, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	the Society for Free Radical Research Japan 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636582/ https://www.ncbi.nlm.nih.gov/pubmed/37970545 http://dx.doi.org/10.3164/jcbn.22-122

Ejemplares similares

TRIM62 knockdown by inhibiting the TLR4/NF-κB pathway and NLRP3 inflammasome attenuates cognitive impairment induced by diabetes in mice
por: Nong, Xiting, et al.
Publicado: (2023)

SENP7 knockdown inhibited pyroptosis and NF-κB/NLRP3 inflammasome pathway activation in Raw 264.7 cells
por: Li, Xun, et al.
Publicado: (2020)

Hydrogen Sulfide Contributes to Uterine Quiescence Through Inhibition of NLRP3 Inflammasome Activation by Suppressing the TLR4/NF-κB Signalling Pathway
por: Chen, Zixi, et al.
Publicado: (2021)

LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy
por: Yi, Hong, et al.
Publicado: (2017)

Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR
por: Leng, Bin, et al.
Publicado: (2019)

Caffeine Inhibits NLRP3 Inflammasome Activation by Downregulating TLR4/MAPK/NF-κB Signaling Pathway in an Experimental NASH Model
por: Vargas-Pozada, Eduardo E., et al.
Publicado: (2022)

Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB signaling pathway
por: Liu, Jie, et al.
Publicado: (2021)

Palmitic acid stimulates NLRP3 inflammasome activation through TLR4-NF-κB signal pathway in hepatic stellate cells
por: Dong, Zhixia, et al.
Publicado: (2020)

Catalpol Alleviates Depression by Inhibiting NLRP3 Inflammasome via TLR4/MAPK/NF-Kb Pathway
por: Liang, Xuemei, et al.
Publicado: (2023)

Dihydromyricetin attenuates Escherichia coli lipopolysaccharide-induced ileum injury in chickens by inhibiting NLRP3 inflammasome and TLR4/NF-κB signalling pathway
por: Chang, Yicong, et al.
Publicado: (2020)

NEK7 inhibition attenuates Aβ(42)-induced cognitive impairment by regulating TLR4/NF-κB and the NLRP3 inflammasome in mice
por: Li, Peng, et al.
Publicado: (2023)

Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation
por: Tang, Shun, et al.
Publicado: (2023)

Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways
por: Chen, Shiyan, et al.
Publicado: (2021)

Dietary Fatty Acid Regulation of the NLRP3 Inflammasome via the TLR4/NF-κB Signaling Pathway Affects Chondrocyte Pyroptosis
por: Jin, Xin, et al.
Publicado: (2022)

Inhibition of Bruton's TK regulates macrophage NF‐κB and NLRP3 inflammasome activation in metabolic inflammation
por: Purvis, Gareth S.D., et al.
Publicado: (2020)

Dexmedetomidine inhibits the NF-κB pathway and NLRP3 inflammasome to attenuate papain-induced osteoarthritis in rats
por: Cheng, Fang, et al.
Publicado: (2019)

Knockdown of NEAT1 induces tolerogenic phenotype in dendritic cells by inhibiting activation of NLRP3 inflammasome
por: Zhang, Maomao, et al.
Publicado: (2019)

Polydatin Inhibits NLRP3 Inflammasome in Dry Eye Disease by Attenuating Oxidative Stress and Inhibiting the NF-κB Pathway
por: Park, Bongkyun, et al.
Publicado: (2019)

Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway
por: Li, Zeyu, et al.
Publicado: (2019)

Caffeine prevents hyperoxia-induced lung injury in neonatal mice through NLRP3 inflammasome and NF-κB pathway
por: Chen, Shangqin, et al.
Publicado: (2020)

Activation of the alpha 7 nicotinic acetylcholine receptor mitigates osteoarthritis progression by inhibiting NF-κB/NLRP3 inflammasome activation and enhancing autophagy
por: Zhu, Xianjie, et al.
Publicado: (2021)

Dopamine activates NF-κB and primes the NLRP3 inflammasome in primary human macrophages
por: Nolan, R.A., et al.
Publicado: (2019)

Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia
por: Zhang, Yang, et al.
Publicado: (2021)

Silibinin Downregulates the NF-κB Pathway and NLRP1/NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia
por: Matias, Mariana Leticia, et al.
Publicado: (2019)

Baicalin mitigates cognitive impairment and protects neurons from microglia‐mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF‐κB signaling pathway
por: Jin, Xin, et al.
Publicado: (2019)

(−)-Epicatechin Ameliorates Monosodium Urate-Induced Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and the NF-κB Signaling Pathway
por: Wu, Chenxi, et al.
Publicado: (2022)

Scropolioside B Inhibits IL-1β and Cytokines Expression through NF-κB and Inflammasome NLRP3 Pathways
por: Zhu, Tiantian, et al.
Publicado: (2014)

Canagliflozin Ameliorates NLRP3 Inflammasome-Mediated Inflammation Through Inhibiting NF-κB Signaling and Upregulating Bif-1
por: Niu, Yaoyun, et al.
Publicado: (2022)

BAFF Blockade Attenuates DSS-Induced Chronic Colitis via Inhibiting NLRP3 Inflammasome and NF-κB Activation
por: Zhang, Ying, et al.
Publicado: (2022)

Qingwenzhike Prescription Alleviates Acute Lung Injury Induced by LPS via Inhibiting TLR4/NF-kB Pathway and NLRP3 Inflammasome Activation
por: Zhang, Cai, et al.
Publicado: (2021)

Inhibiting the NLRP3 Inflammasome
por: El-Sharkawy, Lina Y., et al.
Publicado: (2020)

MUC1 attenuates neutrophilic airway inflammation in asthma by reducing NLRP3 inflammasome-mediated pyroptosis through the inhibition of the TLR4/MyD88/NF-κB pathway
por: Liu, Lu, et al.
Publicado: (2023)

Forsythia suspensa (Thunb.) Vahl extract ameliorates ulcerative colitis via inhibiting NLRP3 inflammasome activation through the TLR4/MyD88/NF‐κB pathway
por: Tong, Xiao, et al.
Publicado: (2023)

LuQi Formula Ameliorates Myocardial Fibrosis by Suppressing TLR4/MyD88/NF-κB Pathway and NLRP3 Inflammasome Activation in Mice with Myocardial Infarction
por: Zhang, Xiaoqing, et al.
Publicado: (2022)

TLR9 regulates NLRP3 inflammasome activation via the NF-kB signaling pathway in diabetic nephropathy
por: Shen, Jinfeng, et al.
Publicado: (2022)

TLR4 Enhances Cerebral Ischemia/Reperfusion Injury via Regulating NLRP3 Inflammasome and Autophagy
por: Mao, Li, et al.
Publicado: (2023)

CD200Fc reduces LPS-induced IL-1β activation in human cervical cancer cells by modulating TLR4-NF-κB and NLRP3 inflammasome pathway
por: He, Aiqin, et al.
Publicado: (2017)

Mycoplasma gallisepticum triggers immune damage in the chicken thymus by activating the TLR-2/MyD88/NF-κB signaling pathway and NLRP3 inflammasome
por: Chen, Chunli, et al.
Publicado: (2020)

HMGB1 mediates microglia activation via the TLR4/NF-κB pathway in coriaria lactone induced epilepsy
por: Shi, Yunbo, et al.
Publicado: (2018)

MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation
por: Liu, Wen, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_18b5cispfie7se8j3ri9c17dl9