ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m(6)A modification-mediated RNA stability control

N(6)-methyladenosine (m(6)A) RNA modification controls numerous cellular processes. To what extent these post-transcriptional regulatory mechanisms play a role in hematopoiesis has not been fully elucidated. We here show that the m(6)A demethylase alkB homolog 5 (ALKBH5) controls mitochondrial ATP p...

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Detalles Bibliográficos
Autores principales: Gao, Yimeng, Zimmer, Joshua T., Vasic, Radovan, Liu, Chengyang, Gbyli, Rana, Zheng, Shu-Jian, Patel, Amisha, Liu, Wei, Qi, Zhihong, Li, Yaping, Nelakanti, Raman, Song, Yuanbin, Biancon, Giulia, Xiao, Andrew Z., Slavoff, Sarah, Kibbey, Richard G., Flavell, Richard A., Simon, Matthew D., Tebaldi, Toma, Li, Hua-Bing, Halene, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636609/
https://www.ncbi.nlm.nih.gov/pubmed/37742191
http://dx.doi.org/10.1016/j.celrep.2023.113163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636609/
https://www.ncbi.nlm.nih.gov/pubmed/37742191
http://dx.doi.org/10.1016/j.celrep.2023.113163

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