Cargando…

Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats

BACKGROUND: Heart transplantation (HTX) is the standard treatment for end-stage heart failure. However, reperfusion following an ischemic period can contribute to myocardial injury. Neutrophil infiltration, along with the subsequent release of tissue-degrading neutrophil elastase (NE)-related serine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Baoer, Korkmaz, Brice, Kraft, Patricia, Mayer, Tobias, Sayour, Alex A., Grundl, Marc A., Domain, Roxane, Karck, Matthias, Szabó, Gábor, Korkmaz-Icöz, Sevil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636924/ https://www.ncbi.nlm.nih.gov/pubmed/37946197 http://dx.doi.org/10.1186/s12967-023-04659-6

Ejemplares similares

Graft Preservation Solution DuraGraft(®) Alleviates Vascular Dysfunction Following In Vitro Ischemia/Reperfusion Injury in Rats
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2021)

Preservation solution Custodiol containing human alpha-1-antitrypsin improves graft recovery after prolonged cold ischemic storage in a rat model of heart transplantation
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2023)

Bone Marrow Culture-Derived Conditioned Medium Recovers Endothelial Function of Vascular Grafts following In Vitro Ischemia/Reperfusion Injury in Diabetic Rats
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2022)

Conditioned Medium from Mesenchymal Stem Cells Alleviates Endothelial Dysfunction of Vascular Grafts Submitted to Ischemia/Reperfusion Injury in 15-Month-Old Rats
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2021)

Mesenchymal stem cell-derived conditioned medium protects vascular grafts of brain-dead rats against in vitro ischemia/reperfusion injury
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2021)

Aspirin Reduces Ischemia-Reperfusion Injury Induced Endothelial Cell Damage of Arterial Grafts in a Rodent Model
por: Veres, Gábor, et al.
Publicado: (2022)

Ethical Decision Diagrams on Donation After Cardiocirculatory Death Heart Transplantation Considering Organ Preservation Techniques
por: Saemann, Lars, et al.
Publicado: (2020)

Left-ventricular hypertrophy in 18-month-old donor rat hearts was not associated with graft dysfunction in the early phase of reperfusion after cardiac transplantation–gene expression profiling
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2021)

Comparison of donor hearts from hypoxic cardiac arrest followed by warm ischemia and from exsanguination as non-beating donor models in rat heart transplantation
por: Li, Shiliang, et al.
Publicado: (2015)

The Sodium-Glucose Cotransporter-2 Inhibitor Canagliflozin Alleviates Endothelial Dysfunction Following In Vitro Vascular Ischemia/Reperfusion Injury in Rats
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2021)

Improvement of Left Ventricular Graft Function Using an Iron-Chelator-Supplemented Bretschneider Solution in a Canine Model of Orthotopic Heart Transplantation
por: Szabó, Gábor, et al.
Publicado: (2022)

Prediction Model for Contractile Function of Circulatory Death Donor Hearts Based on Microvascular Flow Shifts During Ex Situ Hypothermic Cardioplegic Machine Perfusion
por: Saemann, Lars, et al.
Publicado: (2022)

Pharmacological preconditioning with the guanylate cyclase activator cinaciguat (BAY 58-2667) protects against reperfusion injury after cardiopulmonary bypass
por: Radovits, Tamás, et al.
Publicado: (2009)

Acute canagliflozin treatment protects against in vivo myocardial ischemia–reperfusion injury in non-diabetic male rats and enhances endothelium-dependent vasorelaxation
por: Sayour, Alex Ali, et al.
Publicado: (2019)

Improving Diastolic and Microvascular Function in Heart Transplantation with Donation after Circulatory Death
por: Saemann, Lars, et al.
Publicado: (2023)

Comparison of the Reverse-Remodeling Effect of Pharmacological Soluble Guanylate Cyclase Activation With Pressure Unloading in Pathological Myocardial Left Ventricular Hypertrophy
por: Ruppert, Mihály, et al.
Publicado: (2019)

Endothelial Dysfunction of Bypass Graft: Direct Comparison of In Vitro and In Vivo Models of Ischemia-Reperfusion Injury
por: Veres, Gábor, et al.
Publicado: (2015)

Cytokine Adsorber Use during DCD Heart Perfusion Counteracts Coronary Microvascular Dysfunction
por: Saemann, Lars, et al.
Publicado: (2022)

Cysteine Protease Cathepsins in Atherosclerotic Cardiovascular Diseases
por: Wu, Hongxian, et al.
Publicado: (2018)

Pressure overload-induced systolic heart failure is associated with characteristic myocardial microRNA expression signature and post-transcriptional gene regulation in male rats
por: Ruppert, Mihály, et al.
Publicado: (2023)

Mild Type 2 Diabetes Mellitus Reduces the Susceptibility of the Heart to Ischemia/Reperfusion Injury: Identification of Underlying Gene Expression Changes
por: Korkmaz-Icöz, Sevil, et al.
Publicado: (2015)

Phosphodiesterase-5 inhibition delays cardiac dilation and improves myocardial function in a rat model of heart failure due to chronic volume overload
por: Loganathan, Sivakkanan, et al.
Publicado: (2009)

Pharmacological activation of soluble guanylate cyclase activator protects the heart against isoproterenol-induced myocardial ischemia in rats
por: Korkmaz, Sevil, et al.
Publicado: (2009)

Cathepsin F Cysteine Protease of the Human Liver Fluke, Opisthorchis viverrini
por: Pinlaor, Porntip, et al.
Publicado: (2009)

Cysteine protease cathepsin B mediates radiation-induced bystander effects
por: Peng, Yu, et al.
Publicado: (2017)

Cathepsin F of Teladorsagia circumcincta is a recently evolved cysteine protease
por: Sloan, Sarah, et al.
Publicado: (2020)

Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S
por: Haerteis, Silke, et al.
Publicado: (2012)

Odanacatib, a Cathepsin K Cysteine Protease Inhibitor, Kills Hookworm In Vivo
por: Vermeire, Jon J., et al.
Publicado: (2016)

Upregulation of Cysteine Protease Cathepsin X in the 6-Hydroxydopamine Model of Parkinson’s Disease
por: Pišlar, Anja, et al.
Publicado: (2018)

Rational design of thioamide peptides as selective inhibitors of cysteine protease cathepsin L
por: Phan, Hoang Anh T., et al.
Publicado: (2021)

Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells
por: Quilles Junior, José C., et al.
Publicado: (2019)

Stimulation of soluble guanylate cyclase improves donor organ function in rat heart transplantation
por: Benke, Kálmán, et al.
Publicado: (2020)

Cysteine Cathepsin Protease Inhibition: An update on its Diagnostic, Prognostic and Therapeutic Potential in Cancer
por: Soond, Surinder M., et al.
Publicado: (2019)

Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases
por: Yoon, Michael C., et al.
Publicado: (2022)

Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation
por: Rehm, Salome R. T., et al.
Publicado: (2019)

Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production
por: Podvin, Sonia, et al.
Publicado: (2018)

Neutrophils play a major role in the destruction of the olfactory epithelium during SARS-CoV-2 infection in hamsters
por: Bourgon, Clara, et al.
Publicado: (2022)

The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease
por: Lowther, Jonathan, et al.
Publicado: (2009)

The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer †
por: Stoka, Veronika, et al.
Publicado: (2023)

Impact of the Warhead of Dipeptidyl Keto Michael Acceptors on the Inhibition Mechanism of Cysteine Protease Cathepsin L
por: Fernández-de-la-Pradilla, Adrián, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dhhl0v61kqmbj0gv45hqkjmlni