A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau

BACKGROUND: Intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark of Alzheimer’s disease (AD). However, mouse models imitating AD-exclusive neuronal tau pathologies are lacking. METHODS: We generated a new tet-on transgenic mouse model expressing truncated human tau N1-368 (te...

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Detalles Bibliográficos
Autores principales: Gao, Yang, Wang, Yuying, Lei, Huiyang, Xu, Zhendong, Li, Shihong, Yu, Haitao, Xie, Jiazhao, Zhang, Zhentao, Liu, Gongping, Zhang, Yao, Zheng, Jie, Wang, Jian-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637005/
https://www.ncbi.nlm.nih.gov/pubmed/37950283
http://dx.doi.org/10.1186/s40035-023-00379-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637005/
https://www.ncbi.nlm.nih.gov/pubmed/37950283
http://dx.doi.org/10.1186/s40035-023-00379-5

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