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A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau
BACKGROUND: Intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark of Alzheimer’s disease (AD). However, mouse models imitating AD-exclusive neuronal tau pathologies are lacking. METHODS: We generated a new tet-on transgenic mouse model expressing truncated human tau N1-368 (te...
Autores principales: | Gao, Yang, Wang, Yuying, Lei, Huiyang, Xu, Zhendong, Li, Shihong, Yu, Haitao, Xie, Jiazhao, Zhang, Zhentao, Liu, Gongping, Zhang, Yao, Zheng, Jie, Wang, Jian-Zhi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637005/ https://www.ncbi.nlm.nih.gov/pubmed/37950283 http://dx.doi.org/10.1186/s40035-023-00379-5 |
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