Big data- and machine learning-based analysis of a global pharmacovigilance database enables the discovery of sex-specific differences in the safety profile of dual IL4/IL13 blockade

Background: Due to its apparent efficacy and safety, dupilumab, a monoclonal antibody that blocks Interleukin 4 (IL-4) and Interleukin 13 (IL-13), has been approved for treating T-helper 2 (Th2) disorders. However, adverse effects like local injection site reactions, conjunctivitis, headaches, and n...

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Detalles Bibliográficos
Autores principales: Sharif, Kassem, Omar, Mahmud, Lahat, Adi, Patt, Yonatan Shneor, Amital, Howard, Zoabi, Ghanem, Bragazzi, Nicola Luigi, Watad, Abdulla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637473/
https://www.ncbi.nlm.nih.gov/pubmed/37954855
http://dx.doi.org/10.3389/fphar.2023.1271309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637473/
https://www.ncbi.nlm.nih.gov/pubmed/37954855
http://dx.doi.org/10.3389/fphar.2023.1271309

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