TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation

The TMEM127 gene encodes a transmembrane protein of poorly known function that is mutated in pheochromocytomas, neural crest-derived tumors of adrenomedullary cells. Here, we report that, at single-nucleus resolution, TMEM127-mutant tumors share precursor cells and transcription regulatory elements...

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Detalles Bibliográficos
Autores principales: Guo, Qianjin, Cheng, Zi-Ming, Gonzalez-Cantú, Hector, Rotondi, Matthew, Huelgas-Morales, Gabriela, Ethiraj, Purushoth, Qiu, Zhijun, Lefkowitz, Jonathan, Song, Wan, Landry, Bethany N., Lopez, Hector, Estrada-Zuniga, Cynthia M., Goyal, Shivi, Khan, Mohammad Aasif, Walker, Timothy J., Wang, Exing, Li, Faqian, Ding, Yanli, Mulligan, Lois M., Aguiar, Ricardo C.T., Dahia, Patricia L.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637630/
https://www.ncbi.nlm.nih.gov/pubmed/37659079
http://dx.doi.org/10.1016/j.celrep.2023.113070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637630/
https://www.ncbi.nlm.nih.gov/pubmed/37659079
http://dx.doi.org/10.1016/j.celrep.2023.113070

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