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Genome-wide census of ATF4 binding sites and functional profiling of trait-associated genetic variants overlapping ATF4 binding motifs

Activating Transcription Factor 4 (ATF4) is an important regulator of gene expression in stress responses and developmental processes in many cell types. Here, we catalogued ATF4 binding sites in the human genome and identified overlaps with trait-associated genetic variants. We probed these genetic...

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Detalles Bibliográficos
Autores principales: Örd, Tiit, Örd, Daima, Adler, Priit, Örd, Tõnis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637723/
https://www.ncbi.nlm.nih.gov/pubmed/37906604
http://dx.doi.org/10.1371/journal.pgen.1011014