Cargando…
Genome-wide census of ATF4 binding sites and functional profiling of trait-associated genetic variants overlapping ATF4 binding motifs
Activating Transcription Factor 4 (ATF4) is an important regulator of gene expression in stress responses and developmental processes in many cell types. Here, we catalogued ATF4 binding sites in the human genome and identified overlaps with trait-associated genetic variants. We probed these genetic...
Autores principales: | Örd, Tiit, Örd, Daima, Adler, Priit, Örd, Tõnis |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637723/ https://www.ncbi.nlm.nih.gov/pubmed/37906604 http://dx.doi.org/10.1371/journal.pgen.1011014 |
Ejemplares similares
-
Pharmacological or TRIB3-Mediated Suppression of ATF4 Transcriptional Activity Promotes Hepatoma Cell Resistance to Proteasome Inhibitor Bortezomib
por: Örd, Tiit, et al.
Publicado: (2021) -
Amino Acid Availability Controls TRB3 Transcription in Liver through the GCN2/eIF2α/ATF4 Pathway
por: Carraro, Valérie, et al.
Publicado: (2010) -
A human-specific VNTR in the TRIB3 promoter causes gene expression variation between individuals
por: Örd, Tiit, et al.
Publicado: (2020) -
The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation
por: Shan, Jixiu, et al.
Publicado: (2016) -
Trib3 Is Developmentally and Nutritionally Regulated in the Brain but Is Dispensable for Spatial Memory, Fear Conditioning and Sensing of Amino Acid-Imbalanced Diet
por: Örd, Tiit, et al.
Publicado: (2014)