Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma

BACKGROUND: The overactivation of NF-κB signaling is a key hallmark for the pathogenesis of extranodal natural killer/T cell lymphoma (ENKTL), a very aggressive subtype of non-Hodgkin’s lymphoma yet with rather limited control strategies. Previously, we found that the dysregulated exportin-1 (also k...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, He, Liu, Meisuo, Tian, Xibao, Wang, Haina, Gao, Jiujiao, Li, Hanrui, Zhao, Zhehuan, Liu, Yu, Liu, Caigang, Chen, Xuan, Yang, Yongliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637774/
https://www.ncbi.nlm.nih.gov/pubmed/37888961
http://dx.doi.org/10.7554/eLife.80625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637774/
https://www.ncbi.nlm.nih.gov/pubmed/37888961
http://dx.doi.org/10.7554/eLife.80625

Ejemplares similares