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Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma

BACKGROUND: The overactivation of NF-κB signaling is a key hallmark for the pathogenesis of extranodal natural killer/T cell lymphoma (ENKTL), a very aggressive subtype of non-Hodgkin’s lymphoma yet with rather limited control strategies. Previously, we found that the dysregulated exportin-1 (also k...

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Detalles Bibliográficos
Autores principales:	Liu, He, Liu, Meisuo, Tian, Xibao, Wang, Haina, Gao, Jiujiao, Li, Hanrui, Zhao, Zhehuan, Liu, Yu, Liu, Caigang, Chen, Xuan, Yang, Yongliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637774/ https://www.ncbi.nlm.nih.gov/pubmed/37888961 http://dx.doi.org/10.7554/eLife.80625

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