Indoxyl sulfate induced frailty in patients with end-stage renal disease by disrupting the PGC-1α–FNDC5 axis

Objective: Sarcopenia or frailty is common among patients with chronic kidney disease (CKD). The protein-bound uremic toxin indoxyl sulfate (IS) is associated with frailty. IS induces apoptosis and disruption of mitochondrial activity in skeletal muscle. However, the association of IS with anabolic...

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Detalles Bibliográficos
Autores principales: Hou, Yi-Chou, Liao, Min-Tser, Tsai, Kuo-Wang, Zheng, Cai-Mei, Chiu, Hui-Wen, Lu, Kuo-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637807/
https://www.ncbi.nlm.nih.gov/pubmed/37878003
http://dx.doi.org/10.18632/aging.205141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637807/
https://www.ncbi.nlm.nih.gov/pubmed/37878003
http://dx.doi.org/10.18632/aging.205141

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