An interpretable Alzheimer’s disease oligogenic risk score informed by neuroimaging biomarkers improves risk prediction and stratification

INTRODUCTION: Stratification of Alzheimer’s disease (AD) patients into risk subgroups using Polygenic Risk Scores (PRS) presents novel opportunities for the development of clinical trials and disease-modifying therapies. However, the heterogeneous nature of AD continues to pose significant challenge...

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Detalles Bibliográficos
Autores principales: Suh, Erica H., Lee, Garam, Jung, Sang-Hyuk, Wen, Zixuan, Bao, Jingxuan, Nho, Kwangsik, Huang, Heng, Davatzikos, Christos, Saykin, Andrew J., Thompson, Paul M., Shen, Li, Kim, Dokyoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637854/
https://www.ncbi.nlm.nih.gov/pubmed/37953885
http://dx.doi.org/10.3389/fnagi.2023.1281748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637854/
https://www.ncbi.nlm.nih.gov/pubmed/37953885
http://dx.doi.org/10.3389/fnagi.2023.1281748

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