The mitochondrial amidoxime reducing component—from prodrug-activation mechanism to drug-metabolizing enzyme and onward to drug target

The mitochondrial amidoxime–reducing component (mARC) is one of five known molybdenum enzymes in eukaryotes. mARC belongs to the MOSC domain superfamily, a large group of so far poorly studied molybdoenzymes. mARC was initially discovered as the enzyme activating N-hydroxylated prodrugs of basic ami...

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Detalles Bibliográficos
Autores principales: Struwe, Michel A., Scheidig, Axel J., Clement, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
JBC Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637980/
https://www.ncbi.nlm.nih.gov/pubmed/37778733
http://dx.doi.org/10.1016/j.jbc.2023.105306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637980/
https://www.ncbi.nlm.nih.gov/pubmed/37778733
http://dx.doi.org/10.1016/j.jbc.2023.105306

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