Variations of intronic branchpoint motif: identification and functional implications in splicing and disease

The branchpoint (BP) motif is an essential intronic element for spliceosomal pre-mRNA splicing. In mammals, its sequence composition, distance to the downstream exon, and number of BPs per 3´ splice site are highly variable, unlike the GT/AG dinucleotides at the intron ends. These variations appear...

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Detalles Bibliográficos
Autores principales: Xie, Jiuyong, Wang, Lili, Lin, Ren-Jang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638238/
https://www.ncbi.nlm.nih.gov/pubmed/37949953
http://dx.doi.org/10.1038/s42003-023-05513-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638238/
https://www.ncbi.nlm.nih.gov/pubmed/37949953
http://dx.doi.org/10.1038/s42003-023-05513-7

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