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Variations of intronic branchpoint motif: identification and functional implications in splicing and disease

The branchpoint (BP) motif is an essential intronic element for spliceosomal pre-mRNA splicing. In mammals, its sequence composition, distance to the downstream exon, and number of BPs per 3´ splice site are highly variable, unlike the GT/AG dinucleotides at the intron ends. These variations appear...

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Detalles Bibliográficos
Autores principales:	Xie, Jiuyong, Wang, Lili, Lin, Ren-Jang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638238/ https://www.ncbi.nlm.nih.gov/pubmed/37949953 http://dx.doi.org/10.1038/s42003-023-05513-7

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