Aggregation of alpha-synuclein disrupts mitochondrial metabolism and induce mitophagy via cardiolipin externalization

Accumulation of α-synuclein aggregates in the substantia nigra pars compacta is central in the pathophysiology of Parkinson’s disease, leading to the degeneration of dopaminergic neurons and the manifestation of motor symptoms. Although several PD models mimic the pathological accumulation of α-synu...

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Detalles Bibliográficos
Autores principales: Lurette, Olivier, Martín-Jiménez, Rebeca, Khan, Mehtab, Sheta, Razan, Jean, Stéphanie, Schofield, Mia, Teixeira, Maxime, Rodriguez-Aller, Raquel, Perron, Isabelle, Oueslati, Abid, Hebert-Chatelain, Etienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638290/
https://www.ncbi.nlm.nih.gov/pubmed/37949858
http://dx.doi.org/10.1038/s41419-023-06251-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638290/
https://www.ncbi.nlm.nih.gov/pubmed/37949858
http://dx.doi.org/10.1038/s41419-023-06251-8

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