SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway

SIRT1 (NAD-dependent protein deacetylase sirtuin-1), a class III histone deacetylase acting as a tumor suppressor gene, is downregulated in oral cancer cells. Non-apoptotic doses of cisplatin (CDDP) downregulate SIRT1 expression advocating the mechanism of drug resistance. SIRT1 downregulation orche...

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Detalles Bibliográficos
Autores principales: Patra, Srimanta, Singh, Amruta, Praharaj, Prakash P., Mohanta, Nitish K., Jena, Mrutyunjay, Patro, Birija S., Abusharha, Ali, Patil, Shankargouda, Bhutia, Sujit K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638388/
https://www.ncbi.nlm.nih.gov/pubmed/37949849
http://dx.doi.org/10.1038/s41419-023-06232-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638388/
https://www.ncbi.nlm.nih.gov/pubmed/37949849
http://dx.doi.org/10.1038/s41419-023-06232-x

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