Cargando…
Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra
Here we present a deep learning-based image analysis platform (DLAP), tailored to autonomously quantify cell numbers, and fluorescence signals within cellular compartments, derived from RNAscope or immunohistochemistry. We utilised DLAP to analyse subtypes of tyrosine hydroxylase (TH)-positive dopam...
Autores principales: | Burkert, Nicole, Roy, Shoumik, Häusler, Max, Wuttke, Dominik, Müller, Sonja, Wiemer, Johanna, Hollmann, Helene, Oldrati, Marvin, Ramirez-Franco, Jorge, Benkert, Julia, Fauler, Michael, Duda, Johanna, Goaillard, Jean-Marc, Pötschke, Christina, Münchmeyer, Moritz, Parlato, Rosanna, Liss, Birgit |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638391/ https://www.ncbi.nlm.nih.gov/pubmed/37950046 http://dx.doi.org/10.1038/s42003-023-05441-6 |
Ejemplares similares
-
Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease
por: Duda, Johanna, et al.
Publicado: (2016) -
Non-linear developmental trajectory of electrical phenotype in rat substantia nigra pars compacta dopaminergic neurons
por: Dufour, Martial A, et al.
Publicado: (2014) -
Refining the Identity and Role of Kv4 Channels in Mouse Substantia Nigra Dopaminergic Neurons
por: Haddjeri-Hopkins, Alexis, et al.
Publicado: (2021) -
NCS-1 Deficiency Affects mRNA Levels of Genes Involved in Regulation of ATP Synthesis and Mitochondrial Stress in Highly Vulnerable Substantia nigra Dopaminergic Neurons
por: Simons, Carsten, et al.
Publicado: (2019) -
Activity-dependent regulation of NMDA receptors in substantia nigra dopaminergic neurones
por: Wild, Angela R, et al.
Publicado: (2014)